216,105 transcriptional signatures of cellular perturbations constructed using the LINCS pilot phase L1000. The chemical perturbagen and individual shRNA signatures are created by aggregating (ie averaging) Level 4 data for biological replicates as defined by the signatures metadata. Only signatures designated to be reproducible and self-connected ("gold") by the Broad institute are represented. Consensus Gene Signatures (CGS) are constructed by further aggregating signatures of individual shRNA perturbations. Signatures are based only on the 978 Landmark Genes measured directly by the L1000 assay.

Keywords: L1000 | Cmap | Connectivity map | Transcriptomics | BROAD |

Category: assays

Last updated on 13th Apr 2022